Aesthetic Medicine · since 1998 · Zagreb & Daruvar
Profhilo in Croatia
Profhilo is an injectable treatment intended to improve skin hydration, elasticity, and quality, without adding volume or deliberately changing the contours of the face.
Profhilo is intended for people who want to improve the hydration, elasticity, and overall quality of their skin without adding volume. The protocol for the face generally includes two treatments, four weeks apart, and the result is assessed once it is complete. Before we begin, we assess the condition of your skin, the indication, and the change that is realistic to expect.
Is this for me?
What Profhilo is, and how it differs from a filler
Profhilo is an injectable preparation of hyaluronic acid that contains molecules of high and low molecular weight in the form of stable hybrid complexes. Two milliliters of the preparation contain 64 milligrams of hyaluronic acid, 32 milligrams of each kind. Stabilization is achieved through a thermal process, without the chemical cross-linkers used in classic fillers, and the product has carried the European mark of conformity since 2015.
A dermal filler and Profhilo are applied with different goals. A filler is applied at a specific spot to replace volume or change the contours of the face. Profhilo spreads through the tissue and is intended to improve skin hydration, elasticity, and quality, without deliberate volumization.
What bioremodeling means
Bioremodeling refers to gradual changes in the structure of the skin, including processes related to collagen and elastin, rather than the replacement of volume at a specific spot. The effect is not immediate — it develops over several weeks, which is why the result of Profhilo is not assessed right after the first treatment.
What Profhilo does not do
Profhilo does not replace lost volume, does not lift markedly descended contours, and is not intended to remove expression lines. It is also not intended to deliberately change the shape of the face. If the main problem is loss of volume, pronounced laxity, or expression lines, another procedure may be more appropriate.
How it is performed
What a Profhilo treatment with us looks like
The skin is first cleansed, and the preparation is then injected at five predetermined points on each side of the treated area. The technique is called BAP, and the layout of the points is adapted to the anatomy and to the distribution of the preparation with a limited number of injections. Besides the face, the treatment is also performed on the neck, the décolletage, and the hands.
- Number of treatments
- 2 treatments, 4 weeks apart
- Anesthesia
- Agreed at the exam
- Recovery
- Redness and minor swelling most often subside within the first days; special recovery is generally not needed
- Performed by
- Mario Bartol, MD
The BAP technique and the two-treatment protocol
The published protocol calls for two treatments, four weeks apart. The change develops gradually, and the full effect is assessed once the protocol is complete. The price of €400.00 applies to one treatment for the face.
What to expect in the first days
Immediately after the treatment, redness, minor swelling, or a bruise may appear at the injection points. Redness and swelling most often subside within the first days, while a bruise may last somewhat longer. Special recovery is generally not needed, and the return to everyday activities depends on how your skin reacts.
More pronounced reactions, including late swelling or nodules, are described more rarely. In worldwide post-market surveillance, over three years and among more than 40,000 treated patients, twelve reports of side effects were recorded, none of which was rated as serious. Since these are voluntary reports by physicians, the authors caution that underreporting of milder reactions cannot be ruled out.
See the full price listWhy us
Why choose us for Profhilo
Since 1998
The Polyclinic has been operating for more than 27 years, with the continuity of the same family across two generations.
Two generations of the family
The Polyclinic was founded by a surgeon and an anesthesiologist, and today it is led by their daughter.
Assessment before the treatment
At the exam we assess the condition of your skin, the indication, and the change that can realistically be expected.
Three connected fields
The Polyclinic brings together laser medicine, aesthetic surgery, and aesthetic medicine.
Medical premises and operating rooms
More than 1,000 m² in Zagreb and Daruvar, with four operating rooms with air-recuperation systems.
Zagreb and Daruvar
The same team and the same standard at both locations, from the consultation to the follow-up visit.
Price of a single treatment
The price of €400.00 applies to one treatment for the face. The protocol generally includes two treatments.
Continuity of follow-up
For any possible later reaction or assessment of the result, you turn to the team that performed the treatment.
Honest about the limits
When Profhilo is not the right treatment, or should be postponed
With markedly lax skin, Profhilo cannot make up for weakened tissue support, nor can it achieve the effect of a surgical or other lifting procedure. It is also not intended to replace lost volume. If a marked and immediately visible change to the contours of the face is expected, Profhilo is generally not the right treatment.
“Profhilo is more appropriate when skin laxity is not pronounced. With a greater loss of support, another procedure needs to be considered.”
Circumstances in which we postpone the treatment
The treatment is postponed in the case of an active infection or inflammation at the application site. International expert recommendations on late inflammatory reactions also list a recent dental procedure, active autoimmune disease, and a recent viral illness or vaccination as circumstances that call for caution or postponement. The safety of preparations of this kind during pregnancy and breastfeeding has not been established, so the treatment is not performed during that period.
That is why the exam also includes questions about recent illnesses, vaccination, dental procedures, and other circumstances that can affect the safety of the treatment.
Why trust us
What the evidence says about Profhilo
For Profhilo there is published laboratory and clinical literature. Laboratory research has shown increased expression of elastin and of markers of tissue renewal, while clinical studies record improved skin hydration and reduced water loss through the skin.
Most of those studies are open-label, cover small samples and short follow-up periods, and some were conducted with the manufacturer's support. The results should therefore be interpreted with those methodological limitations in mind.
Profhilo or Sunekos
Profhilo and Sunekos differ in composition, application technique, and protocol. For the face, Profhilo is generally applied in two treatments, four weeks apart, while Sunekos involves a larger number of visits. The choice is based on the condition of your skin, the expected change, and your ability to complete the recommended protocol.
| Sunekos | Profhilo | |
|---|---|---|
| What it is | An injectable biostimulator based on non-cross-linked hyaluronic acid and amino acids | An injectable preparation of stable hybrid complexes of hyaluronic acid |
| Composition | Sunekos 1200 with high-molecular-weight hyaluronic acid and Sunekos performa with low-molecular-weight hyaluronic acid; both contain six amino acids | 64 mg of hyaluronic acid in 2 ml, of which 32 mg high and 32 mg low molecular weight |
| How it is applied | With a mesotherapy technique, through multiple shallow injections across the treated area | With the BAP technique, at five points on each side of the treated area |
| Where we apply it | Face, the area around the eyes, forehead, neck, décolletage, backs of the hands | Face, neck, décolletage, hands |
| Number of treatments | Most often three to four, at intervals of 7 to 14 days | Two, four weeks apart |
| When the effect shows | Gradually, over the course of the protocol | One to two weeks after the first application, the full effect after the second |
| Repetition | The need for and timing of repetition are assessed individually after the protocol is complete | The need for and timing of repetition are assessed individually after the protocol is complete |
| What the evidence says | A systematic review and meta-analysis from 2026 record improvement in wrinkles and dermal thickness, with the quality of evidence rated as moderate to very low | Multiple studies, mostly open-label and on small samples, with published safety data from worldwide post-market surveillance |
| What it does not do | Does not replace lost volume and is not intended to correct pronounced laxity | Does not replace lost volume and is not intended to correct pronounced laxity |
| Typical indications | Thin, dry, or dehydrated skin, fine lines, and uneven texture; also applied to younger skin for maintenance | Reduced skin hydration, tone, and elasticity without pronounced laxity |
| Price | Sunekos 1200: €360.00 · Sunekos performa: €290.00 · Sunekos – package of 3 treatments: €990.00 | Profhilo face 2 ml: €400.00 · Profhilo body 2x3 ml: €750.00 |
Sunekos
What it is
An injectable biostimulator based on non-cross-linked hyaluronic acid and amino acids
Composition
Sunekos 1200 with high-molecular-weight hyaluronic acid and Sunekos performa with low-molecular-weight hyaluronic acid; both contain six amino acids
How it is applied
With a mesotherapy technique, through multiple shallow injections across the treated area
Where we apply it
Face, the area around the eyes, forehead, neck, décolletage, backs of the hands
Number of treatments
Most often three to four, at intervals of 7 to 14 days
When the effect shows
Gradually, over the course of the protocol
Repetition
The need for and timing of repetition are assessed individually after the protocol is complete
What the evidence says
A systematic review and meta-analysis from 2026 record improvement in wrinkles and dermal thickness, with the quality of evidence rated as moderate to very low
What it does not do
Does not replace lost volume and is not intended to correct pronounced laxity
Typical indications
Thin, dry, or dehydrated skin, fine lines, and uneven texture; also applied to younger skin for maintenance
Price
Sunekos 1200: €360.00 · Sunekos performa: €290.00 · Sunekos – package of 3 treatments: €990.00
Profhilo
What it is
An injectable preparation of stable hybrid complexes of hyaluronic acid
Composition
64 mg of hyaluronic acid in 2 ml, of which 32 mg high and 32 mg low molecular weight
How it is applied
With the BAP technique, at five points on each side of the treated area
Where we apply it
Face, neck, décolletage, hands
Number of treatments
Two, four weeks apart
When the effect shows
One to two weeks after the first application, the full effect after the second
Repetition
The need for and timing of repetition are assessed individually after the protocol is complete
What the evidence says
Multiple studies, mostly open-label and on small samples, with published safety data from worldwide post-market surveillance
What it does not do
Does not replace lost volume and is not intended to correct pronounced laxity
Typical indications
Reduced skin hydration, tone, and elasticity without pronounced laxity
Price
Profhilo face 2 ml: €400.00 · Profhilo body 2x3 ml: €750.00
The table compares composition, method of application, protocol, and price. The choice of preparation still depends on the condition of your skin, the indication, and the expected change, which are assessed at the exam.
Neither of these two preparations is a substitute for botulinum toxin for expression lines, nor for a filler when volume needs to be replaced. Both are primarily intended to improve skin quality, not to deliberately change the contours of the face.
Who we are
Who performs the Profhilo treatment, and where
The treatment is performed by Mario Bartol, MD, specialist in surgery and a member of the Polyclinic's professional team since 2008. His work focuses on injectable and laser procedures.
During both visits, at both locations, the same team of nurses accompanies you. Continuity of the team matters for assessing the result once the protocol is complete and for monitoring any possible later reactions.
Meet the whole team
After the protocol
How the result is assessed after two treatments
The result is assessed at a follow-up visit once the protocol is complete, by comparing the condition of your skin with photographs taken before the treatment. The change develops over several weeks and can be hard to notice from day to day. Published measurements record an increase in skin hydration and improvement in its texture and tone, with an effect followed in studies for up to about six months.
Profhilo does not stop the natural aging of the skin. The need for and timing of repeating the protocol are assessed individually.
Price
The price of a Profhilo treatment in Zagreb and Daruvar
Profhilo face 2 ml costs €400.00, and Profhilo body 2x3 ml €750.00. The protocol for the face generally includes two treatments, one month apart.
Prices are the same at both locations. You can see the full price list on the Price list page, and arrange an appointment through the Contact page. Other procedures in this field can be found under Face & Neck Treatments.
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Profhilo face 2 ml
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Profhilo body 2x3 ml
The listed price applies to one treatment. For the face, two treatments are generally performed, one month apart.
See the full price listPatient reviews
What our patients say
Reviews taken from our Google Business profiles, Zagreb and Daruvar, translated from Croatian.
★★★★★
“All praise for Polyclinic Maletić in Daruvar! I had lip augmentation with fillers and I am very satisfied with the result. I would especially like to praise Dr. Mario Bartol, who is extremely kind and professional and has a wonderful approach to patients, which made me feel comfortable and safe throughout the treatment. All the nurses are also very kind, helpful, and professional. I warmly recommend them to anyone considering aesthetic treatments!”
★★★★★
“Since high school I watched the double chin I inherited from my father become more and more pronounced — and 15 years later, the double chin is gone. A big thank you to Dr. Maletić and the whole team for making my wish come true. The procedure was painless, as was the recovery, and the results were visible after just a few days. The whole team was extremely kind and cheerful, and the atmosphere very pleasant. I left the polyclinic satisfied, and when I saw, two days after the swelling went down, that the double chin was gone, my satisfaction knew no bounds. I warmly recommend Polyclinic Maletić.”
★★★★★
“My experience with breast augmentation with Dr. Maletić in Daruvar was excellent. I am extremely satisfied with the result. All the nurses are very kind and professional. I absolutely recommend them.”
★★★★★
“Laser acne treatment is the only treatment that helped me, and I would not choose any other facial treatment over it. Dr. Ines is one of the kindest people I have ever met and always has useful advice. Kind staff and top-level service — I warmly recommend her to everyone!”
★★★★★
“I had a wart on my face removed by laser. A very professional service with excellent results. The wart was quite large, but after just one treatment it was gone. All recommendations!”
★★★★★
“I recently had a varicose vein procedure. All praise to the whole team.”
★★★★★
“Blepharoplasty, 4D laser, and double chin. Perfect. All recommendations!”
★★★★★
“The best team of physicians, extremely professional and kind. I have been loyal to Polyclinic Maletić for more than 10 years and I am always satisfied with the results. Thank you.”
★★★★★
“I came to Dr. Maletić with a big problem and a lot of stress. I was met with such warm empathy and kindness, and patience in answering all my questions. Thank you, Dr. Maletić, for the advice and sincere support. I know I can always turn to her for advice, and that means a lot to me. The staff of the Zagreb polyclinic are also very helpful and kind. My thanks to them as well.”
★★★★★
“Dr. Maletić’s practice, both in Daruvar and in Zagreb — and I have had several procedures — I can only recommend, because I felt very comfortable and in expert hands there!”
Questions and answers
Frequently asked questions
Is the Profhilo treatment painful?
The preparation is injected at five points on each side, so there are few injections and the treatment is short. A brief stinging sensation is felt, which passes in a few seconds, and sensitivity varies from person to person.
How many Profhilo treatments are needed?
The published protocol calls for two treatments, four weeks apart. The price of €400.00 applies to one treatment for the face.
When are the results of Profhilo visible?
The change generally begins to show one to two weeks after the first application, and the full effect is assessed after the second. That is why we do not make the first assessment of the result before the protocol is complete.
What is the difference between Profhilo and a dermal filler?
A dermal filler adds volume at a specific spot and can change the contours of the face. Profhilo is not intended for volumization, but for improving skin hydration, elasticity, and quality. The treatments are therefore chosen according to different indications.
Profhilo or Sunekos — which one to choose?
Both treatments are intended to improve skin quality, and neither is intended to add volume. They differ in composition, application technique, and the number of visits, so the choice is based on the condition of your skin, the expected change, and your ability to complete the full protocol. A comparison table with composition, protocols, and prices is on this page.
Are there situations in which the treatment should be postponed?
Yes. We postpone the treatment in the case of an active infection or inflammation at the application site, and caution is also needed after a recent dental procedure, a recent viral illness, or vaccination, because late inflammatory reactions have been described in those circumstances. The safety of the preparation during pregnancy and breastfeeding has not been established.
What is the price of a Profhilo treatment?
Profhilo face 2 ml costs €400.00 per treatment, and the protocol generally calls for two treatments. The price is published in our price list.